What was this cartoon called?

It was only on at 4am here in Australia so I only saw it a couple of times. From memory it revolved around family life, kind of like the Simpsons except the family were mutants. I also vaguely remember that it had someone in it from either the Simpsons or Futurama. I thought it might have been Nancy Cartwright or Katey Sagel but I looked them up on IMDB and it wasn't either of them. Does anyone know what the show was called?